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#IOTA CARRAGEENAN BULK UPDATE#
We reserve the right to change or update information and to correct errors, inaccuracies, or omissions at any time without prior notice.
We cannot and do not guarantee the accuracy or completeness of any information, including prices, product images, specifications, availability, and services. The products or services available on our Service may be mispriced, described inaccurately, or unavailable, and we may experience delays in updating information on the Service and in our advertising on other web sites. AVAILABILITY, ERRORS & INACCURACIES - We are constantly updating our offerings of products and services on the Service. We reserve the right to refuse or cancel your order if fraud or an unauthorized or illegal transaction is suspected. PURCHASES - We reserve the right to refuse or cancel your order at any time for certain reasons including but not limited to: product or service availability, errors in the description or price of the product or service, error in your order or other reasons.
We are unable to ship to the territories (Northwest Territories, Yukon, and Nunavut). Gourmetwarehouse.ca is unable to ship to some PO boxes, hotels, and a few limited areas. SHIPPING LIMITATIONS & EXCLUSIONS - We do not ship electrical products outside the province of British Columbia.
#IOTA CARRAGEENAN BULK FULL#
To reflect the policies of the shipping companies we use, all weights will be rounded up to the next full pound. Please also note that the shipping rates for many items we sell are weight-based. ONTARIO, QUEBEC, AND EASTERN PROVINCES Shipping Rate starting at $18.25 for 500g max parcel weight or as low as $29.89 - When you place an order, we will estimate shipping for you based on the availability of your items, and the shipping option(s) you choose. ALBERTA, MANITOBA, SASKATCHEWAN Shipping Rate starting at $17.25 for 500g max parcel weight or as low as $23.21 BRITISH COLUMBIA Shipping Rate starting as low as: $16.00
#IOTA CARRAGEENAN BULK FREE#
IN-STORE PICKUP / CURBSIDE CONTACTLESS PARKING PICKUP: Free (option available to customers with a billing address located in British Columbia). Note that due to restrictions on some products, we are not shipping outside Canada. (high molecular weight fucoidan from Fucus vesiculosus), CMC (carboxymethylcellulose), HPMC (hydroxypropylmethylcellulose), and Gal-4-SO4 (galacatose-4-sulfate).We can ship to any address within Canada. (high molecular weight fucoidan from Undaria pinnatifida), Fuc.F.v. (kappa-carrageenan), lambda-carr, (lambda-carrageenan), Fuc.U.p. Data represent means of triplicates ± standard deviation. Luciferase data were corrected with metabolic data (Alamar blue) derived from a parallel plate with identical set-up. Infection efficiency was determined by measuring the luciferase activity 48 hours post infection. 100 μg/ml and 10 μg/ml sulfated polymers and 100 μg/ml non-sulfated polymers and galactose-4-sulfate were incubated with the virus for 30 minutes before infection. Mock infected and mock treated infected cells served as negative control (0% infection) and positive control (100% infection control y-axis), respectively. ACE2-HEK293cells/well were infected with SARS-CoV-2 Spike pseudotyped lentivirus (Luc reporter). Neutralization assay with iota-carrageenan compared to other sulfated and non-sulfated polymers as well as a sulfated sugar. Accordingly, our in vitro data on SARS-CoV-2 spike pseudotyped lentivirus and replication competent SARS-CoV-2 suggest that administration of iota-carrageenan may be an effective and safe prophylaxis or treatment for SARS-CoV-2 infections. In vitro data on iota-carrageenan against various Rhino- and endemic Coronaviruses showed similar IC50 values and translated readily into clinical effectiveness when a nasal spray containing iota-carrageenan demonstrated a reduction of severity and duration of symptoms of common cold caused by various respiratory viruses.
Experiments with patient isolated wild type SARS-CoV-2 virus showed an inhibition of replication in a similar range. SARS-CoV-2 spike pseudotyped lentivirus particles were efficiently neutralized with an IC50 value of 2.6 μg/ml iota-carrageenan. Here, we show that iota-carrageenan can inhibit the cell entry of the SARS-CoV-2 spike pseudotyped lentivirus in a dose dependent manner. Attachment and entry of coronaviruses including SARS-CoV-2 is mainly mediated by the spike glycoprotein. In the absence of a vaccine and other effective prophylactic or therapeutic countermeasures the severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) remains a significant public health threat.
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